| Animal Research - STS / ISS |
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FIT |
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 Characterize
the effects that the space flight environment has on the fly immune
system cellular and molecular biology, and functional ability to combat
bacterial or fungal infection.- Determine if the space flight environment alters the microbial pathogenesis
of an insect fungal pathogen.
- Ground experiments to assess proton radiation effects on whole organism
physiology, including immunity.
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 FIT
(Fungal Pathogenesis, Tumerogenesis, and Effects on Host Immunity
in Space) Quad Chart |
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CBTM-2, CBTM-3 |
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Provided the capability to use the microgravity environment for evaluation
of new pharmaceutical candidates in small mammals. Results may expedite
the review of new pharmaceuticals for allowing immediate access to new
disease treatments. |
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CBTM-2, CBTM-3 |
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Commercial Biomedical Test Module - 3 (CBTM-3) uses a validated mouse
model to examine the effectiveness of an experimental therapeutic as
a possible countermeasure for muscle atrophy. |
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Mouse Drawer System Biospecimen Sharing |
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Mice Drawer System (MDS) is an Italian Space Agency investigation
that will use a validated mouse model to investigate the genetic mechanisms
underlying bone mass loss in microgravity. Research conducted with the
MDS is an analog to the human research program, which has the objective
to extend the human presence safely beyond low Earth orbit. |
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Mouse Immunology-1 |
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 This
innovative experiment will determine the effects of spaceflight on the
rodent immune system: 1) whether initial specific activation of T-lymphocytes
is intact and, 2) whether memory of prior exposure to a foreign antigen
is retained by T-lymphocytes during spaceflight. Two Animal Enclosure
Modules (AEMs) will accommodate eight female mice each for the flight
experiment. The AEMs are series re-flown hardware and provide
a reliable habitat for rodents during spaceflight. |
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Mouse
Immunology-1 Quad Chart |
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Mouse Immunology-2
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 This
flight project will evaluate the total effects of spaceflight on the
ability of the host to combat a viral pathogen. The specific aims of
the project are: Aim 1. Characterize viral replication in the lung and
nasal turbinates, disease severity, including airway obstruction and
hyper-responsiveness (AHR), and histopathology of the airways. Aim 2. Determine
the profile of IFN- a/b and innate cytokine response to viral infection
in BAL and nasal tissue, as well as other proteins by 2DE gel and MALDI-TOF.
Aim 3. Characterize viral replication in the lung and nasal turbinates,
disease severity, & histopathology of the airways. Aim 4. Profile
IFN- a/b and innate cytokine response to infection in BAL and nasal
tissue |
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Mouse
Immunology-2 Quad Chart |
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